Hairless Cat For Sale Missouri

A recently developed breed of cat, termed the lykoi , presents a unique form of hypotrichia . Individual hairs of the coat are either normal coloration or all white, producing a roaning effect. Lykoi owners have genotyped their cats for all the known cat fur type mutations, including variants in KRT71, which cause the hairless sphynx breed, Devon rex and Selkirk rex curly hair, and none of these variants are present in the lykoi cats. The breeding program was established in 2011 by a veterinarian who has constantly monitored health in the cats . No health concerns have been identified in the lykoi other than the lymphocytic mural folliculitis.

The lykoi has been genotyped for all the known cat fur type mutations, including variants in KRT71, which cause the hairless sphynx breed, Devon rex and Selkirk rex curly hair, and none of these variants are present in the lykoi cats. The breeding program was established in 2011 by a veterinarian, who has constantly monitored health in the cats . Several phenotypic traits in cats are heterogeneous, including the variants for the loci Long, Tailless, and the classic pattern of Tabby, which are each caused by four different mutations in the genes FGF5 , TBX1 , and LVRN , respectively. Variation in the phenotypic presentations caused by these different variants is undocumented. Only the TBX1 variants define breeds, the Manx and Cymric, which is a longhaired Manx, the Long and Tabby variants segregate within and amongst breeds. A few breeds have unique and breed defining variants, such as Scottish folds , Selkirk rex , Devon rex, and sphynx .

Like the Manx, the lykoi will be a unique breed that segregates for several variants within the same gene, HR, that present a similar phenotype . Unlike the Manx variants , the variants that cause the hypotrichosis are recessive and do not cause additional health concerns known to date. The only documented abnormality is the sparse haircoat resulting from abnormal follicular development and lymphocytic mural folliculitis. Some variants are not perpetuated as they tend to cause more periodic hair loss, suspected to be associated with sex hormone levels . The lykoi breeders can now use genetic testing to monitor the variants in the population and to realize possible associations with phenotypic differences in compound heterozygotes.

Additional haplotype analyses of flanking variants could determine if the eight reported founder lineages with the exon 8 variant are identical by descent or identical by state and represent multiple de novo mutation events at the same site. A few breeds have unique and breed defining variants, such as Scottish folds , Selkirk rex , Devon rex, and Sphynx . The domestic cat numbers over 94 million in the USA alone, occupies households as a companion animal, and, like humans, suffers from cancer and common and rare diseases. However, genome-wide sequence variant information is limited for this species.

To empower trait analyses, a new cat genome reference assembly was developed from PacBio long sequence reads that significantly improve sequence representation and assembly contiguity. The whole genome sequences of 54 domestic cats were aligned to the reference to identify single nucleotide variants and structural variants . Across all cats, 16 SNVs predicted to have deleterious impacts and in a singleton state were identified as high priority candidates for causative mutations. The SNV is found in cats segregating for feline mediastinal lymphoma and is a candidate for inherited cancer susceptibility.

SV analysis revealed a complex deletion coupled with a nearby potential duplication event that was shared privately across three unrelated dwarfism cats and is found within a known dwarfism associated region on cat chromosome B1. This SV interrupted UDP-glucose 6-dehydrogenase , a gene involved in the biosynthesis of glycosaminoglycans. Importantly, UGDH has not yet been associated with human dwarfism and should be screened in undiagnosed patients.

The new high-quality cat genome reference and the compilation of sequence variation demonstrate the importance of these resources when searching for disease causative alleles in the domestic cat and for identification of feline biomedical models. Author summary The practice of genomic medicine is predicated on the availability of a high quality reference genome and an understanding of the impact of genome variation. The generation of Felis_catus_9.0, a new high quality reference genome for the domestic cat, helps facilitate the expansion of genomic medicine into the felis lineage.

Using Felis_catus_9.0 we analyze the landscape of genomic variation from a collection of 54 cats within the context of human gene constraint. The distribution of variant impacts in cats is correlated with patterns of gene constraint in humans, indicating the utility of this reference for identifying novel mutations that cause phenotypes relevant to human and cat health. Moreover, structural variant analysis revealed a novel variant for feline dwarfism in UGDH , a gene that has not been associated with dwarfism in any other species, suggesting a role for UGDH in cases of undiagnosed dwarfism in humans. Hairlessness is a breed-specific feature selected for in some dog breeds but a rare abnormality in some others such as Scottish Deerhounds .

In SDs, the affected puppies are born with sparse hair but lose it within the first 2 months leaving the dogs completely hairless. The previous studies have implicated variants in FOXI3 and SGK3 in hairlessness; however, the known variants do not explain hairlessness in all breeds such as SDs. We investigated the genetic cause in 66 SDs, including a litter with two hairless dogs.

We utilized a combined approach of genome-wide homozygosity mapping and whole-genome sequencing of a hairless SD followed by recessive filtering according to a recessive model against 340 control genomes. Only two homozygous-coding variants were discovered in the homozygosity regions, including a 1-bp insertion in exon 2 of SGK3. This results in a predicted frameshift and very early truncation (49/490 amino acids) of the SGK3 protein. Additional screening of the recessive variant demonstrated a full segregation with the hairlessness and a 12% carrier frequency in the SD breed.

The variant was not found in the related Irish Wolfhound breed. This study identifies the second hairless variant in the SGK3 gene in dogs and further highlights its role as a candidate gene for androgen-independent hair loss or alopecia in human. Although over 50 cat breeds are identified by different cat associations and registries worldwide, fewer than 30 are demonstrated to be genetically distinct . For example, the Selkirk rex has strong genetic influences from Persians and British shorthair , although the curly coat is a novelty phenotype identified in the past few decades in Northwestern USA . One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age.

The diagnosis of early-onset progressive retinal atrophy was supported by reduced direct and consensual pupillary light reflexes, phenotypic presence of retinal degeneration, and a non-recordable electroretinogram with negligible amplitudes in both eyes. Whole genome sequencing, conducted on two unaffected parents and one affected offspring was compared to a variant database from 51 domestic cats and a Pallas cat, revealed 50 candidate variants that segregated concordantly with the PRA phenotype. Testing in additional affected cats confirmed that cats homozygous for a 2 base pair deletion within IQ calmodulin-binding motif-containing protein-1 , the gene that encodes for nephrocystin-5 , had vision loss. The variant segregated concordantly in other related individuals within the pedigree supporting the identification of a recessively inherited early-onset feline PRA. Analysis of the black-footed cat studbook suggests additional captive cats are at risk. Genetic testing for IQCB1 and avoidance of matings between carriers should be added to the species survival plan for captive management.

Because of its slim appearance and energetic personality, the Cornish Rex is often called the "greyhound of the cat fancy." To keep the breed line pure, breeders can only breed a male and a female with the same wavy hair. This is because the "spontaneous genetic mutation that causes the thin hair coat and whiskers to grow in pattern waves instead of straight" is a recessive gene, write feline experts Benjamin and Lynette Hart in their book on cat breeds, Your Ideal Cat. Hair follicle morphogenesis during embryogenesis is induced by Wnt/β-catenin signaling that leads to the development of the HF placode .

Postnatal HF morphogenesis is regulated by SGK3 through modulation of β-catenin dependent transcription processes . Foxi3 has been shown to regulate several aspects of HF development and homeostasis, including stem cell specification during induction . Wnt/β-catenin activation is correlated with the presence of nuclear HR protein at anagen initiation.

Although HR function is not recognized during initial hair morphogenesis, HR controls the timing and location of HF regeneration via Wnt-signaling . Keratins are highly expressed in the terminally differentiated cells in the growing hair follicle, specifically the inner root sheath . Thus, the genes demonstrated to cause atrichia in various species are due to disruptions of the interwoven pathways and cascades leading to mammalian hair development and expression. Novelty breeds, such as Selkirk rex and Scottish folds, are characterized by novel "breed-defining" variants, retain high genetic variation , but often modify their type but by cross-breeding with established breeds that have the desired structural "look". An inherited neurologic syndrome in a family of mixed-breed Oriental cats has been characterized as forebrain commissural malformation, concurrent with ventriculomegaly and interhemispheric cysts.

However, the genetic basis for this autosomal recessive syndrome in cats is unknown. Forty-three cats were genotyped on the Illumina Infinium Feline 63K iSelect DNA Array and used for analyses. Genome-wide association studies, including a sib-transmission disequilibrium test and a case-control association analysis, and homozygosity mapping, identified a critical region on cat chromosome A3. Short-read whole genome sequencing was completed for a cat trio segregating with the syndrome.

A homozygous 7 bp deletion in growth differentiation factor 7 (c.221_227delGCCGCGC [p.Arg74Profs]) was identified in affected cats, by comparison to the 99 Lives Cat variant dataset, validated using Sanger sequencing and genotyped by fragment analyses. This variant was not identified in 192 unaffected cats in the 99 Lives dataset. In mice, GDF7 mRNA is expressed within the roof plate when commissural axons initiate ventrally-directed growth. This finding emphasized the importance of GDF7 in the neurodevelopmental process in the mammalian brain.

A genetic test can be developed for use by cat breeders to eradicate this variant. The lykoi is a very recently developed novelty breed with a sparse hair coat and black and white hair roaning, hence named from the Greek term lycos for wolf. To maintain diversity in the founding population, the breeders have actively recruited cats with similar phenotypes for the breeding program, resulting in six different "foundation" lineages identified in this study from 16 potential founders. The breed is growing in popularity due to the novelty of the appearance, the lack of concern for health problems and the charismatic name and nature. The breed was accepted for full championship showing by TICA in May 2017 .

The Manx breed is genetically distinct from the Japanese Bobtail breed, another naturally occurring insular breed. The Japanese Bobtail has a markedly different appearance from the Manx, and is characterized by almond-shaped eyes, a triangular face, long ears, and lean body, like many other Asian breeds. The Pixie-bob breed also has a short tail, and may be genetically related to the Manx. More will be clear about tail genetics as more genetic studies are done on cat populations and as DNA testing improves; most domestic animal genetic work has been done with dogs and livestock breeds. The sphynx cat was discovered when a domestic cat gave birth to a hairless kitten in 1966 in Toronto, Canada. Found to be a natural genetic mutation, sphynx cats have been found worldwide produced naturally, and are the foundation for this unusual breed, according to The Cat Fancier's Association website.

The dramatic drop in costs allowed the first cat's sequencing to be done well ahead of the original schedule. MCGP has already identified the location of the mutation responsible for suppression of Bonnag's tail, the deletion of a single bit of genetic data among 2.8 billion making up the genome. The type arose possibly without existing rex mutation bloodlines (and none of the rex breeds are permitted as out-cross partners with Tasman Manx in Catz breeding guidelines). Depending on length of tail and coat, kittens may sometimes be termed "Tasman Cymric", "Tasman Isle of Man Shorthair" or "Tasman Isle of Man Longhair", but these are not considered separate breeds. The term "Tasman Rex" has been applied to cats with this gene that do not fall into one of the previously mentioned labels , though relation if any to extant Rex mutation breeds is unclear.

All of these additional terms beyond "Tasman Manx" appear to be "recognised", even promulgated by NZCF but without breed standards, and even the permissive Catz registry does not include them as of July 2014. If you have purchased a Sphynx kitten from Stoney Hill and due to circumstances beyond your control find you have to rehome your Sphynx please get in touch with us we may know of someone who would offer. There are several ways that you can find a Sphynx cat for adoption. Consider obtaining pet insurance especially for kittens under 1-year-old which will protect you from uncommon but often fatal FIP.

Discuss the arrival of a new cat with all family members including children so that everyone is prepared and on the same page. Rex who are divided into the Cornish and Devon varieties have short wavy coats with no overcoat layer of fur. Staff is working diligently to process tickets received during the week of April 15th.

The hairless cat breeds like the Sphynx are often the first choice for want-to-be cat owners who are concerned about allergens. While there are no truly hairless cats, the Sphynx's fur feels more like peach fuzz to the touch. This unusual characteristic also means that the breed has less of the dander that can spark an allergy attack, making it hypoallergenic.

A lithe, active, and independent cat, the Sphynx is happy to amuse itself while you're out of the the house, but you may want to invest in a cat tower, as the Sphynx isn't shy when it comes to jumping. Whole genome sequencing has proven a successful genetic approach for the identification of causal gene variants for several phenotypes and diseases in the domestic cat . This study used WGS to identify the causal gene variant for the lykoi presentation in the domestic cats.

The cattery features bald and curly haired domestic cat breeds. Many color photos of cats and kittens and information on how to purchase your own kitten. Sphynx – The skin of a Sphynx has been said to resemble warm suede, not unlike their warm, affectionate personality. Similar to other hairless cat breeds, Sphynx are one the most allergy friendly breeds. Contrary to popular belief, most cats of this breed are not completely hairless, although they appear to be bald all over. That's because their fur is so fine and short, it usually cannot be seen by the human eye.

Welcome to Unique Sphynx thank you for your interest in our beautiful hairless cats. Adopting the Sphynx kitten you are searching to adopt can now possibly occur. These are people who specialize in the breed and really understand their personality traits and how to care for them. TOP OF PAGE ADD NEW SHELTER OR RESCUE GROUP. Many online breeders will ship your Sphynx right to your door including Glorious Sphynx Kittens and My Sphynx Mate.

Many Manx have a small stub of a tail, but Manx cats are best known as being entirely tailless; this is the most distinguishing characteristic of the breed, along with elongated hind legs and a rounded head. Manx cats come in all coat colours and patterns, though all-white specimens are rare, and the coat range of the original stock was more limited. Long-haired variants are sometimes considered a separate breed, the Cymric.

The two HR frameshift variants, including an exon 3 c.1255_1256dupGT, and the exon 18 c.3389insGACA, were identified by the WGS analyses. Products were genotyped with the MassARRAY System with Nanodispenser RS1000 (Agena Bioscience Inc., San Diego, CA, USA). These variants were validated in the WGS cat by Sanger sequencing .

An assay was designed as previously described to genotype the identified variants in pedigree A and the additional cats, using the Agena Bioscience iPLEX Gold Genotyping reagent set (Agena Bioscience Inc., San Diego, CA) . Products were genotyped with the MassARRAY System with Nanodispenser RS1000 (Agena Bioscience Inc., San Diego, CA). Whole genome sequencing has proven a successful genetic approach for the identification of causal variants for several phenotypes and diseases in the domestic cat [30–33]. This study used WGS to identify the causal variant for the lykoi presentation in the domestic cats.

As with all cat breeds, the cat fancy has arrived through observation at a variety of widely held generalisations about the Manx breed as a whole. The Manx is considered a social and gregarious cat, and very attached to humans, but also shy of strangers. The breed is said to be highly intelligent, playful, and in its behaviour reminiscent of dogs. For example, like some Maine Coons and a few other breeds, Manx cats often learn to fetch small thrown objects.

Drug Series On Netflix 2020

Elves While on holiday on a remote island, two siblings discover elves — but not the Christmas kind. But when his passengers reveal their true nature, he must fight to stay alive. The streaming service followed up the success of the first series by bringing another one, this time set in Mexico. These series might be based on real stories, but they often dramatize the events. The characters are shown in a different light and we often grow to root for the bad guys. If you are tired of this moral struggle, then 'Inside the Real Narcos' might work some wonder for you.

An ex-special forces soldier goes on a journey that takes him to the drug kingpins in order to understand how their business affects their lifestyle. This one is for those who would like to educate themselves on drugs and also enjoy watching true crime documentaries. 'Murder Mountain' explores the Humboldt County of North Carolina, its focus being on the marijuana industry in the region.

Apart from growing and selling illegal weed, this place is also known for a string of murders that happened around this region. Then there's the case of people disappearing and their cases still left unresolved. One of the most prominent cases of this place was of the death of a young man named Garret Rodriguez.

In six episodes, the documentary takes you through the marijuana business of the place, how it affects the lives of the people who live around it, and how it has spawned a number of unsolved cases. BBC Two's Giri / Haji, available in the U.S. via Netflix, is already one of the year's best surprises. The hope is that bringing Yuto back will stop a sprawling war that he helped kickstart among the Yakuza factions.

But like Kenzo's investigation into Yuto's disappearance and faked death, Giri /Haji is full of unexpected twists, not just in its narrative but in its form. At the center of the story is the tale of two brothers, yet it's also about forged family and discovering the truth about one's self. The gang war is the framework for the story, which plays out in many ways like Lock, Stock, and Two Smoking Barrels ; and yet, one of its most moving scenes takes place during a quiet, makeshift Yom Kippur dinner regarding atonement. This 2001 docuseries may be the original from which springs the panoply of true crime stories we enjoy today. The Staircase centers upon Michael Peterson, a novelist who called the police to report the sudden death of his wife, Kathleen.

Suspicion almost immediately settles on Peterson himself, and the resulting investigation only makes the whole case weirder. But rather than simply dwell on sordid speculation while we wait for a resolution, the series focuses on the meticulous work of Peterson's defense team. Imagine the suspense film What Lies Beneath crossed with a chess match between two masters of the game, and you'll have an idea of what you're in for. You'll finish the series understanding a lot more about how murder trials work, even if the issues of guilt and innocence end up seeming a lot murkier.

What do you get when you throw Cillian Murphy and Tom Hardy on the screen together? Well yes, that, but I was referring to the brilliant Peaky Blinders. Set in 1919, the series takes its name from a particular street gang that took charge of Birmingham, England shortly after the Great War. Using whatever means necessary to rise through the criminal ranks is war veteran Thomas Shelby, who – along with his family – forms the focus of this gripping crime drama.

While trying to figure out the time loop, she meets a fellow constant perisher, Charlie Barnett as Alan Zavery. Originality has earned Lyonne critical praise, TV award show recognition and lots of love from us. While Making a Murdererbecame a world-wide phenomenon and Tiger Kingis the one that had people compulsively tweeting, it's The Keepersthat feels the most essential. Centered around the unsolved murder of nun Catherine Cesik in 1969, this seven-part docu-series follows the efforts of her former students from Archbishop Keough High School in Baltimore to crack the case.

It's upsetting viewing, and the story will linger with you well after you've finished watching. But the narrative is also respectful of the survivors, who, by sharing their distressing and heartbreaking stories, are able to regain some of the power that was so cruelly taken from them. The question at the heart of this buzzy Netflix series immediately alerts you to what kind of show you're set to be obsessed with.

He's served his prison sentence and, despite having been framed for the murder of his sister Sara, he's now intent on finding the real culprit behind her death. Oh, and seeking revenge, of course – all while finding himself attracted to a woman whose family wronged him all those years ago. The twists and turns in this Mexican drama are fast and furious, keeping you guessing all the way through its every thrilling episode.

Orange Is the New Black is perfectly suited for the Netflix delivery system, if only because it would be agonizing to wait a week for each new episode. The story is based on the real-life events of Piper Kerman, whose book of the same title was the inspiration, but the truth is that the screen version is miles better. Schilling is the engine that drives the plot, and her odd combination of natural serenity mixed with the increasing anger and desperation at the late turn her life has taken strikes the perfect tone for life inside the women's prison. However, this miniseries starring an on-form Toni Collette, Merritt Wever and Kaitlyn Dever is not your typical sensationalist true crime drama. Based on ProPublic/The Marshall Project's 2015 Pulitzer-winning article, 'An Unbelievable Story of Rape,' this sensitive drama about a series of rape cases in the states of Washington and Colorado doesn't focus on the perpetrator.

Instead, this is a story about the survivors of sexual violence, one that's handled with empathy and without melodrama. It doesn't shy away from the trauma these survivors live with, but it never feels gratuitous, even if it is, at times, difficult to watch. Netflix's bilingual series,Narcos,focused its first two seasons on the rise of Pablo Escobar.

Chronicling the Colombian drug lord's wide-reaching operation and the DEA's attempts to stop him, the show has since taken a broader view of the "war on drugs" in that South American country. Ambitious, thrilling, and full of stellar performances by the likes of Wagner Moura, Pedro Pascal, and Paulina García among others, this José Padilha-produced show has clearly set the bar for what a Narco prestige drama can look like. Unbelievable, which came out on Netflix September 2019, is a true crime miniseries consisting of 8 episodes. Starring Toni Collette , Merritt Wever & Kaitlyn Dever , this 4 time Emmy nominated series covers the 2016 Pulitzer Prize winning article "An Unbelievable Story of Rape". The story follows a woman named "Marie" from Lynnwood, Washington who reports to the police that she was raped. After a series of long interrogations by two detectives lacking empathy, Marie ends up saying that her report was false which leads to her being charged with gross misdemeanor for making a false report.

Genuinely, aside from a few single-episode cameos of side characters from Hope and Alaric's TVD/Originals past, the only thing you need to watch to make sense of Legacies is this official promo for the first season. A show inspired by the true story of the first pro female wrestling syndicate in the '80s? GLOW's purely fun comedy, packed with eccentric female characters, teams campiness with underdog triumph and soars. Season 3 progresses deeper into the lives of its diverse ensemble, shifting the series to Las Vegas. A fourth and final season was in the works, but sadly production fell victim to the pandemic and Netflix cancelled the show.

In addition to being one of the best TV shows to tackle the drug theme, the captivating story of Walter White is also widely considered one of the best shows to ever hit the small-screen, period. So, if there's ever an appropriate time to start watching this show, it's now. Based on the novel La Reina del Sur, the show captures stories of different drug lords in America through the lens of Teresa , who is cunning and ruthless. Featuring a bunch of telenovelas like El Chapo and Sean Penn, it is based on an unbelievable true story and is naturally our top recommendation from this list.

She soon discovers she's entered a dangerous web of painful secrets in both the town and the school. This one is good but fairly dark, so check out the preview to see if it fits for you. Most entries on this list deal with addictions that come with the drugs that everyone knows are bad, the ones that can lead to your death. But while we are busy trying to keep our children away from marijuana and cocaine and heroin, there is another form of drug that is taking over their lives. Today's world is of cut-throat competition and one needs to keep their wits about themselves if they hope to survive. Finding it in the above mentioned drugs is popular belief, but there's something else that is a popular choice.

Prescription drugs, especially Adderall, are normally used by people. Comedy vets Jane Fonda and Lily Tomlin headline this superbly bingeable sitcom about two women whose ongoing rivalry comes to a head when their husbands reveal they're in love and want divorces. While Grace and Frankie try to navigate this life-changing revelation alone, they fast become frenemies who wind up sharing a beach house.

Throw in their four kids and their newly-married husbands, and what you're left with is a modern living situation. What starts as an amusing premise over the seasons sprawls into a ripe comedy setup that's all about figuring out life, love, career, health, no matter your age, and how our friends are the one thing we can always rely on. Snowfall tells the story of several characters involved in the crack distribution and how their lives intersect with each other's. These include a Mexican luchador and cartel enforcer, a CIA operative covering up a colleague's drug-induced death, a crime boss' niece, and a young cocaine dealer from a drug-dealing family. Season one follows a murder house, and the stories of the people that died in it. The drama is loosely based on true events that have happened throughout history.

Ozarkhas proven to be an incredibly popular series since it first aired, and a big part of that is the family dynamic that runs throughout it. The series takes a different approach to the drug world here, as it focuses on the financial side, with money laundering to keep the crime undercover. The award-winning Telemundo series has all the hallmarks of contemporary telenovelas. Add in botched facial surgeries, stolen identities, beautiful women, gory deaths, and even a life-threatening illness, and you can rest assured thatEl Señor de los Cielosis as perfect a narco-melodrama as you're likely to find out there.

"You can be a freedom fighter on the front lines of the war on drugs. You can make big money and get sweet love from every señorita that walks by. " That cringeworthy proposition is at the heart of this Scott Eastwood flick where a broke American guy is recruited into joining a paramilitary group that targets Mexican cartels. Set in the dusty Texas desert, Charles Burmeister's action-heavy film centers its action on a beautifully chiseled white guy who eventually gets some semblance of a moral compass when he realizes what the group he's joined is really up to. Created by Laura Ricciardi and Moira Demos, Making a Murderercame out in December, 2015 winning 4 Primetime Emmys in the process.

Following the staggering success which arguably paved the way for true crime docuseries on Netflix, a second season was ordered and came out in October, 2018. This show details the story of Steven Avery, who served 18 years in prison for the wrongful conviction of sexual assault and attempted murder of Penny Beerntsen. After being released and suing the Manitowoc County for wrongful imprisonment, he was once again charged and convicted this time for the murder of Teresa Halbach. At least once or twice in every episode of the brilliant and captivating and wildly entertaining six-part Netflix true crime documentary series "Cocaine Cowboys," there's a revelation that has us exclaiming "Holy …" something. Tap the photo to watch the trailer on NetflixSuspenseful crime drama set in 1980s Galicia, Spain about the rise to power of a young fisherman seduced into becoming a prosperous cocaine smuggler.

You cannot look away from When They See Us or shelter yourself from the blinding truth. On April 19, 1989, 28-year-old Trisha Meli was jogging in Central Park when she was brutally raped and left for dead. In a coma for 12 days, Meli had no memory of what happened to her and was unable to identify her attacker or attackers. The series doesn't shy away from the horrors of what happened to Meli.

A successful white woman left for dead in America's most famous public space did not sit well with New York City. Everyone—the mayor, the district attorney, the police department—wanted her attackers caught. But there are several key decisions Ava DuVernay makes that turns When They See Us into one of the year's, if not the decade's best, programs.

One is the casting of five relatively unknown actors to play the boys. Breaking Bad is a story about disease, drugs, family, profit, power and much, much more. High school chemistry teacher Walter White needs money for his cancer treatment, and realizes he can profit from scientific know-how by cooking meth. Breaking Bad is not just one of the best Netflix shows, but one of the top series ever. How to Sell Drugs Online is set in fictional Rinseln, North Rhine-Westphalia, Germany, and told from the perspective of high-school outcast and nerd Moritz Zimmermann. The series follows Moritz and his fellow friend Lenny Sander attempting to rekindle Moritz's love for ex-girlfriend Lisa Novak, through selling ecstasy online.

Starting off as a small time business, it quickly spirals out of control and Moritz and Lenny learn to deal with the consequences of large scale drug trafficking. This documentary series from National Geographic focuses on the different roles of people involved in the drug world and what their motivations are to sell, deal, ship, etc. different kinds of drugs. It covers the production and sale of drugs as well as the culture and crime that come along with it. Liam Neeson, who has become Hollywood's go-to senior action hero, stars in another bang-bang thriller about a family man seeking revenge on the drug cartel who killed his son. The true story of Colombia's infamously violent and powerful drug cartels fuels this gritty gangster drama series. This television mini-series takes us into the lives of Dhruv and 'Kavya, who've been dating for the last 5 years.

After an immensely popular season 1, the next season is back and has just released on Netflix. Relish and relate to the endless sweet moments experienced by couples in their everyday life with this series. This American romantic musical comedy-drama television series is set around a successful young woman, Rebecca Bunch, who gives up her life in New York and moves to California simply to find love and happiness.

This American crime drama television series is about Walter White, a chemistry teacher who discovers that he has cancer and then gets into the meth-making business to cover for his medical expenses. His priorities change when he starts dealing in partnership with Jesse Pinkman. Queen of the South is based on a novel of the same name, and tells the story of Teresa Mendoza's return to Mexico after 8 years, when she was part of a small-time drug cartel and her boyfriend was murdered.

This time, she returns and decides to take control of her own destiny, including rising in power to the top position in the cartel. Based on true events, this series explores the growth of drug cartels, beginning with the rise of Pablo Escobar in Colombia. There's a mix of English and Spanish as the story is told through the eyes of DEA agent Steve Murphy and his team. This is obviously a violent show about a difficult part of history, but also a very high-quality and nuanced look into the relations between the DEA, Latin American governments, and cartels. Based on real-life events,La niñatells the incredible story of a girl forcibly recruited by theguerillasin Colombia, who then escapes and tries to reintegrate into society.

Although she manages to reunite with her family and even gets into medical school, her past haunts her. Unlike many of the other series in this list, it gives a in-depth look into everyday life for working-class families in Latin America. After watching so many stories about antiheroes, we know that things never end so well for them. No matter how rich they get, how many people they kill in the process and what ends of the Earth they run to escape justice, karma never fails to deliver.

'Drug Lords' follows the stories of such people — from the ones who have been the kings of the trade to the ones who haven't acted as more than simple rooks to carry out business for some other titan they serve. Everyone has a role to play in the drug business, and when the time comes, everyone will pay their dues. A young woman is woken in the night to the sound of a man breaking into her home.